A number of "Independents" from Scotland and northern Ireland came to Lewes after 1682 and to them came the Rev. Samuel Davis in 1691. The Lewes Presbyterian Church was founded in 1692.
The current structure is the third building on this same site, with the first meeting house constructed in 1707. The present church was built in 1832 and has been enlarged many times since.
A steeple to house a 1,000-pound bell was constructed in 1886 but was removed in later years during a general renovation.
The church served Cool Spring and other congregations for nearly 100 years before becoming an exclusive charge in 1873. On one wall is a large cenotaph in memory of the Rev. John Mitchelmore, pastor of the Lewes, Cool Spring and Indian River churches who died in the burning of the steamer William Penn in 1834.
Many interesting tombs are located in the church cemetery, including those of two former Delaware governors, Colonel David Hall and Ebe W. Tunnell.
Other graves of note: